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Most patients begin noticing changes in pain levels, range of motion, and recovery speed during the maintenance phase

The effect of rosiglitazone on cellular growth was associated with cell cycle arrest and with an increase of cyclin-dependent kinase inhibitors p21 (cip1) and cyclin-dependent kinase regulator p27 (kip1), a decrease of cyclin D1, and inactivation of Rb protein

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Patients should be advised to avoid very sweet, fatty, or spicy foods if these exacerbate gastrointestinal symptoms

At the 12mg dose, 28% of participants reported nausea, 24% experienced diarrhea, 21% had constipation, and 17% dealt with some vomiting